Article
Do mtDNA deletions drive premature aging in mtDNA mutator mice?
Aging cell - 1 Aug 2009
Kraytsberg Yevgenya, Simon David K, Turnbull Douglas M, Khrapko Konstantin
Abstract excerpt
Deletions in mitochondrial DNA (mtDNA) have long been suspected to be involved in mammalian aging, but their role remains controversial. Recent research has demonstrated that relatively higher levels of mtDNA deletions correlate with premature aging in mtDNA mutator mice, which led to the conclusion that premature aging in these mice is driven by mtDNA deletions. However, it is reported here that the absolute...
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