Article
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.
eLife - 17 Feb 2023
Sanchez-Contreras Monica, Sweetwyne Mariya T, Tsantilas Kristine A, Whitson Jeremy A, Campbell Matthew D, Kohrn Brenden F, Kim Hyeon Jeong, Hipp Michael J, Fredrickson Jeanne, Nguyen Megan M, Hurley James B, Marcinek David J, Rabinovitch Peter S, Kennedy Scott R
Abstract excerpt
Accumulation of somatic mutations in the mitochondrial genome (mtDNA) has long been proposed as a possible mechanism of mitochondrial and tissue dysfunction that occurs during aging. A thorough characterization of age-associated mtDNA somatic mutations has been hampered by the limited ability to detect low-frequency mutations. Here, we used Duplex Sequencing on eight tissues of an aged mouse cohort to detect...
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