Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.

PLoS genetics - 1 Mar 2011

Ameur Adam, Stewart James B, Freyer Christoph, Hagström Erik, Ingman Max, Larsson Nils-Göran, Gyllensten Ulf

Abstract excerpt

Somatic mutations of mtDNA are implicated in the aging process, but there is no universally accepted method for their accurate quantification. We have used ultra-deep sequencing to study genome-wide mtDNA mutation load in the liver of normally- and prematurely-aging mice. Mice that are homozygous for an allele expressing a proof-reading-deficient mtDNA polymerase (mtDNA mutator mice) have 10-times-higher point...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Mitochondrial
Share to Electron Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Mice, Inbred C57BL

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21455489
DOI: 10.1371/journal.pgen.1002028
PMCID: PMC3063763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.PMID 21455489Read ↗

Germline and somatic mtDNA mutations in mouse aging.Semantic proximity Read ↗

The mtDNA Mutation Spectrum in the Polg Mutator Mouse Reveals Germline and Somatic SelectionSemantic proximity Read ↗

The mtDNA mutation spectrum in the PolG mutator mouse reveals germline and somatic selection.Semantic proximity Read ↗

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.Semantic proximity Read ↗

Mitochondrial DNA mutations and aging: devils in the details?Semantic proximity Read ↗

Mitochondrial haplotype and mito-nuclear matching drive somatic mutation and selection throughout ageing.Semantic proximity Read ↗

Multi-tissue landscape of somatic mtDNA mutations indicates tissue specific accumulation and removal in agingSemantic proximity Read ↗

Random point mutations with major effects on protein-coding genes are the driving force behind premature aging in mtDNA mutator mice.Semantic proximity Read ↗

Single-cell mitochondrial sequencing reveals low-frequency mitochondrial mutations in naturally aging mice.Semantic proximity Read ↗

Age-related accumulation of de novo mitochondrial mutations in mammalian oocytes and somatic tissues.Semantic proximity Read ↗

Ultra-sensitive sequencing reveals an age-related increase in somatic mitochondrial mutations that are inconsistent with oxidative damage.Semantic proximity Read ↗

A mutational gradient drives somatic mutation accumulation in mitochondrial DNA and influences germline polymorphisms and genome compositionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.