Article
The role of mitochondrial DNA mutations in mammalian aging.
PLoS genetics - 23 Feb 2007
Kujoth Gregory C, Bradshaw Patrick C, Haroon Suraiya, Prolla Tomas A
Abstract excerpt
Mitochondrial DNA (mtDNA) accumulates both base-substitution mutations and deletions with aging in several tissues in mammals. Here, we examine the evidence supporting a causative role for mtDNA mutations in mammalian aging. We describe and compare human diseases and mouse models associated with mitochondrial genome instability. We also discuss potential mechanisms for the generation of these mutations and the...
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