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Article

Clonal expansion of mitochondrial DNA deletions is a private mechanism of aging in long-lived animals.

Aging cell - 1 Oct 2018

Lakshmanan Lakshmi Narayanan, Yee Zhuangli, Ng Li Fang, Gunawan Rudiyanto, Halliwell Barry, Gruber Jan

Abstract excerpt

Disruption of mitochondrial metabolism and loss of mitochondrial DNA (mtDNA) integrity are widely considered as evolutionarily conserved (public) mechanisms of aging (López-Otín et al., Cell, 153, 2013 and 1194). Human aging is associated with loss in skeletal muscle mass and function (Sarcopenia), contributing significantly to morbidity and mortality. Muscle aging is associated with loss of mtDNA integrity. In...

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PMID: 30043489
DOI: 10.1111/acel.12814
PMCID: PMC6156498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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