Article
The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
Human molecular genetics - 15 Jul 2009
Schumacher Johannes, Laje Gonzalo, Abou Jamra Rami, Becker Tim, Mühleisen Thomas W, Vasilescu Catalina, Mattheisen Manuel, Herms Stefan, Hoffmann Per, Hillmer Axel M, Georgi Alexander, Herold Christine, Schulze Thomas G, Propping Peter, Rietschel Marcella, McMahon Francis J, Nöthen Markus M, Cichon Sven
Abstract excerpt
Association studies, as well as the initial translocation family study, identified the gene Disrupted-In-Schizophrenia-1 (DISC1) as a risk factor for schizophrenia. DISC1 encodes a multifunctional scaffold protein involved in neurodevelopmental processes implicated in the etiology of schizophrenia. The present study explores the contribution of the DISC locus to schizophrenia using three different approaches: (i)...
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