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Article

Role of DISC1 interacting proteins in schizophrenia risk from genome-wide analysis of missense SNPs.

Annals of human genetics - 1 Nov 2013

Costas Javier, Suárez-Rama Jose Javier, Carrera Noa, Paz Eduardo, Páramo Mario, Agra Santiago, Brenlla Julio, Ramos-Ríos Ramón, Arrojo Manuel

Abstract excerpt

A balanced translocation affecting DISC1 cosegregates with several psychiatric disorders, including schizophrenia, in a Scottish family. DISC1 is a hub protein of a network of protein-protein interactions involved in multiple developmental pathways within the brain. Gene set-based analysis has been proposed as an alternative to individual analysis of single nucleotide polymorphisms (SNPs) to get information from...

Topics

Carrier Proteins
Computational Biology
Datasets as Topic
Epistasis, Genetic
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Mutation, Missense
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Protein Binding

Risk

Schizophrenia

Source

Identifiers

PMID: 23909765
DOI: 10.1111/ahg.12037

Genes

DISC1
AKAP9
DST
MACF1
UTRN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Role of DISC1 interacting proteins in schizophrenia risk from genome-wide analysis of missense SNPs.PMID 23909765Read ↗

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