Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.

Molecular psychiatry - 1 Sept 2009

Hennah W, Thomson P, McQuillin A, Bass N, Loukola A, Anjorin A, Blackwood D, Curtis D, Deary I J, Harris S E, Isometsä E T, Lawrence J, Lönnqvist J, Muir W, Palotie A, Partonen T, Paunio T, Pylkkö E, Robinson M, Soronen P, Suominen K, Suvisaari J, Thirumalai S, St Clair D, Gurling H, Peltonen L, Porteous D

Abstract excerpt

Disrupted in schizophrenia 1 (DISC1) has been associated with risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism and Asperger syndrome, but apart from in the original translocation family, true causal variants have yet to be confirmed. Here we report a harmonized association study for DISC1 in European cohorts of schizophrenia and bipolar disorder. We identify regions of...

Topics

Join the communities discussing this publication.

Bipolar Disorder
Europe
International Cooperation
Neuropsychological Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Psychiatric Status Rating Scales

Source

Identifiers

PMID: 18317464
DOI: 10.1038/mp.2008.22

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder.PMID 18317464Read ↗

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.Semantic proximity Read ↗

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Semantic proximity Read ↗

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.Semantic proximity Read ↗

Association between genes of Disrupted in schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses.Semantic proximity Read ↗

Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations.Semantic proximity Read ↗

DISC1 genetics, biology and psychiatric illnessSemantic proximity Read ↗

DISC1 and DISC2: discovering and dissecting molecular mechanisms underlying psychiatric illness.Semantic proximity Read ↗

Role of DISC1 interacting proteins in schizophrenia risk from genome-wide analysis of missense SNPs.Semantic proximity Read ↗

Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophreniaSemantic proximity Read ↗

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.