Article
Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.
PloS one - 1 Jan 2011
Moens Lotte N, De Rijk Peter, Reumers Joke, Van den Bossche Maarten J A, Glassee Wim, De Zutter Sonia, Lenaerts An-Sofie, Nordin Annelie, Nilsson Lars-Göran, Medina Castello Ignacio, Norrback Karl-Fredrik, Goossens Dirk, Van Steen Kristel, Adolfsson Rolf, Del-Favero Jurgen
Abstract excerpt
In recent years, DISC1 has emerged as one of the most credible and best supported candidate genes for schizophrenia and related neuropsychiatric disorders. Furthermore, increasing evidence--both genetic and functional--indicates that many of its protein interaction partners are also involved in the development of these diseases. In this study, we applied a pooled sample 454 sequencing strategy, to explore the...
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