Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia.

Biochemical and biophysical research communications - 14 Mar 2008

Song Wenjia, Li Wenyan, Feng Jinong, Heston Leonard L, Scaringe William A, Sommer Steve S

Abstract excerpt

The causes of schizophrenia remain elusive. In a large Scottish pedigree, a balanced translocation t(1;11) (q42.1;q14.3) disrupting the DISC1 and DISC2 genes segregates with major mental illness, including schizophrenia and unipolar depression. A frame-shift carboxyl-terminal deletion was reported in DISC1 in an American family, but subsequently found in two controls. A few common structural variants have been...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cohort Studies
Share to Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Minnesota

Share to Mutation, Missense

Share to Nerve Tissue Proteins

Share to Odds Ratio

Share to Risk Assessment

Share to Schizophrenia

Source

Identifiers

PMID: 18164685
DOI: 10.1016/j.bbrc.2007.12.117

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia.PMID 18164685Read ↗

Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder.Semantic proximity Read ↗

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.Semantic proximity Read ↗

The DISC locus in psychiatric illness.Semantic proximity Read ↗

Sequencing of DISC1 pathway genes reveals increased burden of rare missense variants in schizophrenia patients from a northern Swedish population.Semantic proximity Read ↗

Association between a disrupted-in-schizophrenia 1 (DISC1) single nucleotide polymorphism and schizophrenia in a combined Scandinavian case-control sample.Semantic proximity Read ↗

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.Semantic proximity Read ↗

Genetic association between schizophrenia and the DISC1 gene in the Scottish population.Semantic proximity Read ↗

Association study of polymorphisms in the 5' upstream region of human DISC1 gene with schizophrenia.Semantic proximity Read ↗

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.Semantic proximity Read ↗

Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population.Semantic proximity Read ↗

Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia.Semantic proximity Read ↗

Analysis of the DISC1 translocation partner (11q14.3) in genetic risk of schizophrenia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.