Article
Rare disruptive variants in the DISC1 Interactome and Regulome: association with cognitive ability and schizophrenia.
Molecular psychiatry - 1 May 2018
Teng S, Thomson P A, McCarthy S, Kramer M, Muller S, Lihm J, Morris S, Soares D C, Hennah W, Harris S, Camargo L M, Malkov V, McIntosh A M, Millar J K, Blackwood D H, Evans K L, Deary I J, Porteous D J, McCombie W R
Abstract excerpt
Schizophrenia (SCZ), bipolar disorder (BD) and recurrent major depressive disorder (rMDD) are common psychiatric illnesses. All have been associated with lower cognitive ability, and show evidence of genetic overlap and substantial evidence of pleiotropy with cognitive function and neuroticism. Disrupted in schizophrenia 1 (DISC1) protein directly interacts with a large set of proteins (DISC1 Interactome) that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.