Article
Disrupted-in-Schizophrenia-1.
Current psychiatry reports - 1 Apr 2008
Muir Walter J, Pickard Benjamin S, Blackwood Douglas H R
Abstract excerpt
Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the...
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