Disrupted-in-Schizophrenia-1.

doi:10.1007/s11920-008-0025-2

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Article

Disrupted-in-Schizophrenia-1.

Current psychiatry reports - 1 Apr 2008

Muir Walter J, Pickard Benjamin S, Blackwood Douglas H R

Abstract excerpt

Chromosomal abnormalities can be powerful tools to identify genes that influence disease risk. The study of a chromosome translocation that segregated with severe psychiatric illness in a large family led directly to the discovery of a gene disrupted by a chromosomal breakpoint. Disrupted-in-Schizophrenia-1 (DISC1) is now an important candidate risk gene for schizophrenia and affective disorders. We review the...

Topics

Animals
Bipolar Disorder
Chromosome Aberrations
Chromosome Breakage
Chromosome Mapping
DNA Mutational Analysis
Depressive Disorder, Major
Genetic Carrier Screening
Genetic Markers
Humans
Lod Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Multifactorial Inheritance

Nerve Tissue Proteins

Phenotype

Psychotic Disorders

Risk Factors

Source

Open in PubMed

Identifiers

PMID: 18474207
DOI: 10.1007/s11920-008-0025-2

Genes

DISC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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