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Article

Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

20 Apr 2009

Abstract excerpt

It is still unclear whether the BH3-only protein Puma (p53 up-regulated modulator of apoptosis) can prime cells to death and render antiapoptotic BH3-binding Bcl-2 homologues necessary for survival through its ability to directly interact with proapoptotic Bax and activate it. In this study, we provide further evidence, using cell-free assays, that the BH3 domain of Puma binds Bax at an activation site that...

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PMID: 19380879
DOI: 10.1083/jcb.200809153

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