Article
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.
The Journal of biological chemistry - 25 Jun 2010
Gurzov Esteban N, Germano Carla M, Cunha Daniel A, Ortis Fernanda, Vanderwinden Jean-Marie, Marchetti Piero, Zhang Lin, Eizirik Decio L
Abstract excerpt
Type 1 diabetes is an autoimmune disorder characterized by chronic inflammation and pancreatic beta-cell loss. Here, we demonstrate that the proinflammatory cytokine interleukin-1beta, combined with interferon-gamma, induces the expression of the Bcl-2 homology 3 (BH3)-only activator PUMA (p53 up-regulated modulator of apoptosis) in beta-cells. Transcriptional activation of PUMA is regulated by nuclear...
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