Article
The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.
Molecular cell - 3 Dec 2004
Cartron Pierre-François, Gallenne Tristan, Bougras Gwenola, Gautier Fabien, Manero Florence, Vusio Patricia, Meflah Khaled, Vallette François M, Juin Philippe
Abstract excerpt
The mechanism by which some BH3-only proteins of the Bcl-2 family directly activate the "multidomain" proapoptotic member Bax is poorly characterized. We report that the first alpha helix (Halpha1) of Bax specifically interacts with the BH3 domains of Bid and PUMA but not with that of Bad. Inhibition of this interaction, by a peptide comprising Halpha1 or by a mutation in this helix, prevents ligand-induced...
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