Article
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Science (New York, N.Y.) - 9 Feb 2007
Willis Simon N, Fletcher Jamie I, Kaufmann Thomas, van Delft Mark F, Chen Lin, Czabotar Peter E, Ierino Helen, Lee Erinna F, Fairlie W Douglas, Bouillet Philippe, Strasser Andreas, Kluck Ruth M, Adams Jerry M, Huang David C S
Abstract excerpt
A central issue in the regulation of apoptosis by the Bcl-2 family is whether its BH3-only members initiate apoptosis by directly binding to the essential cell-death mediators Bax and Bak, or whether they can act indirectly, by engaging their pro-survival Bcl-2-like relatives. Contrary to the direct-activation model, we show that Bax and Bak can mediate apoptosis without discernable association with the putative...
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