Article

Pre-existing levels of pro-survival proteins and induction of BCL-XL dictate cell fate after p53 activation

2026-07-02

Abstract excerpt

TP53 (also called TRP53 or p53) is a critical tumour suppressor that prevents cancer development by inducing a transcriptional program which can lead to diverse cellular responses, most prominently, cell proliferation arrest/senescence with survival of cells or cell death by apoptosis. Why distinct cell types undergo different outcomes after p53 activation remains unclear. Using integrated RNA-sequencing, proteomi...

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Literature Corpus work: 27565631-e86e-55b5-b7d5-5867865b1cdd
DOI: 10.64898/2026.07.01.735749

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