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Article

Puma, a critical mediator of cell death — one decade on from its discovery

1 Jan 2012

Abstract excerpt

PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent apoptosis and was identified 10 years ago. The PUMA gene is mapped to the long arm of chromosome 19, a region that is frequently deleted in a large number of human cancers. PUMA mediates apoptosis thanks to its ability to directly bind...

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Identifiers

PMID: 23001513
DOI: 10.2478/s11658-012-0032-5

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Puma, a critical mediator of cell death — one decade on from its discoveryPMID 23001513Read ↗

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