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Article

Phosphorylation of Puma modulates its apoptotic function by regulating protein stability.

Cell death & disease - 29 Jul 2010

Fricker M, O'Prey J, Tolkovsky A M, Ryan K M

Abstract excerpt

Puma is a potent BH3-only protein that antagonises anti-apoptotic Bcl-2 proteins, promotes Bax/Bak activation and has an essential role in multiple apoptotic models. Puma expression is normally kept very low, but can be induced by several transcription factors including p53, p73, E2F1 and FOXO3a, whereby it can induce an apoptotic response. As Puma can to bind and inactivate all anti-apoptotic members of the...

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Identifiers

PMID: 21364664
DOI: 10.1038/cddis.2010.38
PMCID: PMC3032554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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