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BH3-Only Proteins Noxa and Puma Are Key Regulators of Induced Apoptosis

9 Feb 2022

Abstract excerpt

Apoptosis is an evolutionarily conserved and tightly regulated cell death pathway. Physiological cell death is important for maintaining homeostasis and optimal biological conditions by continuous elimination of undesired or superfluous cells. The BH3-only pro-apoptotic members are strong inducers of apoptosis. The pro-apoptotic BH3-only protein Noxa activates multiple death pathways by inhibiting the...

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PMID: 35207544
DOI: 10.3390/life12020256

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