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Article

No PUMA, no death: implications for p53-dependent apoptosis.

Cancer cell - 1 Oct 2003

Yu Jian, Zhang Lin

Abstract excerpt

More than a decade ago, it was found that one of the two essential physiological functions of p53 is to selectively destroy stressed cells through apoptosis. Despite the large number of studies describing p53-dependent apoptosis since then, how p53 turns on the apoptotic switch has remained enigmatic. In this issue of Cancer Cell, Jeffers et al. report that knockout of PUMA, a recently identified BH3-only Bcl-2...

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Identifiers

PMID: 14585351
DOI: 10.1016/s1535-6108(03)00249-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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