Article
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis.
Science (New York, N.Y.) - 13 Feb 2004
Chipuk Jerry E, Kuwana Tomomi, Bouchier-Hayes Lisa, Droin Nathalie M, Newmeyer Donald D, Schuler Martin, Green Douglas R
Abstract excerpt
The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that cytosolic localization of endogenous wild-type or trans-activation-deficient p53 was necessary and sufficient for apoptosis. p53 directly activated the proapoptotic Bcl-2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program. p53 also...
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