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Article

The HLA paradox across populations in multiple sclerosis progression: a systematic review.

BMC neurology - 24 Jun 2026

Maghbooli Zhila, Nasir Erfan, Mahdavinasab Fatemeh, Sahraian Mohammad Ali, Shirvani Arash

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) exhibits heterogeneity in disease courses. Although HLA DRB1*15:01 represents the strongest genetic risk factor for MS susceptibility, conferring approximately threefold increased risk, whether this allele similarly influences disease progression remains contentious. METHODS: This systematic review was conducted to clarify the relationship between HLA polymorphisms and the...

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Topics

Humans
Multiple Sclerosis
Disease Progression
Genetic Predisposition to Disease
HLA-DRB1 Chains
Polymorphism, Genetic

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Identifiers

PMID: 42343278
DOI: 10.1186/s12883-026-05100-3
PMCID: PMC13548618

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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