Article
Agrin regulation of alpha3 sodium-potassium ATPase activity modulates cardiac myocyte contraction.
The Journal of biological chemistry - 19 Jun 2009
Hilgenberg Lutz G W, Pham Bryan, Ortega Maria, Walid Saif, Kemmerly Thomas, O'Dowd Diane K, Smith Martin A
Abstract excerpt
Drugs that inhibit Na,K-ATPases, such as digoxin and ouabain, alter cardiac myocyte contractility. We recently demonstrated that agrin, a protein first identified at the vertebrate neuromuscular junction, binds to and regulates the activity of alpha3 subunit-containing isoforms of the Na,K-ATPase in the mammalian brain. Both agrin and the alpha3 Na,K-ATPase are expressed in heart, but their potential for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.