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Article

Implication of geranylgeranyltransferase I in synapse formation.

Neuron - 13 Nov 2003

Luo Zhen G, Je Hyun-Soo, Wang Qiang, Yang Feng, Dobbins G Clem, Yang Zhi-Hua, Xiong Wen C, Lu Bai, Mei Lin

Abstract excerpt

Agrin activates the transmembrane tyrosine kinase MuSK to mediate acetylcholine receptor (AChR) clustering at the neuromuscular junction (NMJ). However, the intracellular signaling mechanism downstream of MuSK is poorly characterized. This study provides evidence that geranylgeranyltransferase I (GGT) is an important signaling component in the Agrin/MuSK pathway. Agrin causes a rapid increase in tyrosine...

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Source

Identifiers

PMID: 14622576
DOI: 10.1016/s0896-6273(03)00695-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Implication of geranylgeranyltransferase I in synapse formation.PMID 14622576Read ↗

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