Article
Agrin regulates neuronal responses to excitatory neurotransmitters in vitro and in vivo.
Molecular and cellular neurosciences - 1 Jan 2002
Hilgenberg Lutz G W, Ho Kathleen D, Lee Daewoo, O'Dowd Diane K, Smith Martin A
Abstract excerpt
Agrin mediates motor neuron-induced differentiation of the postsynaptic apparatus of the neuromuscular junction but its function in brain remains unknown. Here we report that expression of c-fos, induced by activation of nicotinic or glutamatergic receptors, was significantly lower in cortical neurons cultured from agrin-deficient mutant mouse embryos compared to wildtype. Agrin-deficient neurons also exhibited...
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