Article
Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Feb 2008
Zhu Dan, Yang Zhihua, Luo Zhenge, Luo Shiwen, Xiong Wen C, Mei Lin
Abstract excerpt
Agrin, a factor used by motoneurons to direct acetylcholine receptor (AChR) clustering at the neuromuscular junction, initiates signal transduction by activating the muscle-specific receptor tyrosine kinase (MuSK). However, the underlying mechanisms remain poorly defined. Here, we demonstrated that MuSK became rapidly internalized in response to agrin, which appeared to be required for induced AChR clustering....
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