Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New insights into the roles of agrin.

Nature reviews. Molecular cell biology - 1 Apr 2003

Bezakova Gabriela, Ruegg Markus A

Abstract excerpt

The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse, the organization of the cytoskeleton and the amelioration of function in diseased muscle. So the activities of agrin might be of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Genetic Variation
Share to Nervous System Physiological Phenomena

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuromuscular Junction

Share to Neurons

Share to Protein Isoforms

Share to Synapses

Share to Transcription, Genetic

Source

Identifiers

PMID: 12671652
DOI: 10.1038/nrm1074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New insights into the roles of agrin.PMID 12671652Read ↗

Role of Agrin in tissue repair and regeneration: From mechanisms to therapeutic opportunities (Review)Semantic proximity Read ↗

Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.Semantic proximity Read ↗

Agrin is a chimeric proteoglycan with the attachment sites for heparan sulfate/chondroitin sulfate located in two multiple serine-glycine clusters.Semantic proximity Read ↗

Alternative RNA splicing that determines agrin activity regulates binding to heparin and alpha-dystroglycan.Semantic proximity Read ↗

Targeting of recombinant agrin to axonal growth cones.Semantic proximity Read ↗

The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.Semantic proximity Read ↗

LG2 agrin mutation causing severe congenital myasthenic syndrome mimics functional characteristics of non-neural (z−) agrinSemantic proximity Read ↗

The agrin/muscle‐specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junctionSemantic proximity Read ↗

Induction of filopodia-like protrusions by transmembrane agrin: role of agrin glycosaminoglycan chains and Rho-family GTPases.Semantic proximity Read ↗

Injection of a soluble fragment of neural agrin (NT-1654) considerably improves the muscle pathology caused by the disassembly of the neuromuscular junction.Semantic proximity Read ↗

Adeno-Associated Virus-Mediated Mini-Agrin Delivery Is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I.Semantic proximity Read ↗

Implication of geranylgeranyltransferase I in synapse formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.