Article
Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.
The Journal of cell biology - 1 Feb 1995
Gesemann M, Denzer A J, Ruegg M A
Abstract excerpt
Agrin is a basal lamina protein that induces aggregation of acetylcholine receptors (AChRs) and other molecules at the developing neuromuscular junction. Alternative splicing of chick agrin mRNA at two sites, A and B, gives rise to eight possible isoforms of which five are expressed in vivo. Moto...
Topics
- Agrin
- Animals
- Base Sequence
- Cells, Cultured
- Chick Embryo
- DNA, Complementary
- Dose-Response Relationship, Drug
- Enzyme-Linked Immunosorbent Assay
- Genetic Variation
- Mice
- Molecular Sequence Data
- Muscles
- Neuromuscular Junction
- Neurons
- Peptide Fragments
- Precipitin Tests
- Protein Conformation
- RNA Splicing