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Article

Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.

The Journal of cell biology - 6 Sept 1999

Zhou H, Glass D J, Yancopoulos G D, Sanes J R

Abstract excerpt

Agrin released from motor nerve terminals activates a muscle-specific receptor tyrosine kinase (MuSK) in muscle cells to trigger formation of the skeletal neuromuscular junction. A key step in synaptogenesis is the aggregation of acetylcholine receptors (AChRs) in the postsynaptic membrane, a process that requires the AChR-associated protein, rapsyn. Here, we mapped domains on MuSK necessary for its interactions...

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Source

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Identifiers

PMID: 10477765
DOI: 10.1083/jcb.146.5.1133
PMCID: PMC2169478

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.PMID 10477765Read ↗

The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsSemantic proximity Read ↗

Distinct phenotypes of mutant mice lacking agrin, MuSK, or rapsyn.Semantic proximity Read ↗

The muscle protein Dok-7 is essential for neuromuscular synaptogenesis.Semantic proximity Read ↗

Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.Semantic proximity Read ↗

The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapsesSemantic proximity Read ↗

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.Semantic proximity Read ↗

Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.Semantic proximity Read ↗

MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticitySemantic proximity Read ↗

The agrin/muscle‐specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junctionSemantic proximity Read ↗

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization.Semantic proximity Read ↗

Mutations in MUSK causing congenital myasthenic syndrome impair MuSK–Dok-7 interactionSemantic proximity Read ↗

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndromeSemantic proximity Read ↗

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