Article
Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.
Neuron - 1 May 1999
Burgess R W, Nguyen Q T, Son Y J, Lichtman J W, Sanes J R
Abstract excerpt
Agrin induces synaptic differentiation at the skeletal neuromuscular junction (NMJ); both pre- and postsynaptic differentiation are drastically impaired in its absence. Multiple alternatively spliced forms of agrin that differ in binding characteristics and bioactivity are synthesized by nerve and muscle cells. We used surgical chimeras, isoform-specific mutant mice, and nerve-muscle cocultures to determine the...
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