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Article

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.

The Journal of allergy and clinical immunology - 1 May 2009

Suttner Kathrin, Rosenstiel Philip, Depner Martin, Schedel Michaela, Pinto Leonardo A, Ruether Andreas, Adamski Jerzy, Klopp Norman, Illig Thomas, Vogelberg Christian, Schreiber Stefan, von Mutius Erika, Kabesch Michael

Abstract excerpt

BACKGROUND: The T cell-specific T-box transcription factor (TBX21) plays a crucial role in the regulation of the immune system because this factor induces the differentiation of T(H)1 and blocks T(H)2 commitment together with the homeobox transcription factor HLX1. OBJECTIVE: The role of genetic variants in TBX21 alone and in combination with HLX1 polymorphisms was investigated in the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19362357
DOI: 10.1016/j.jaci.2009.02.025

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.PMID 19362357Read ↗

Association analysis of novel TBX21 variants with asthma phenotypes.Semantic proximity Read ↗

T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children.Semantic proximity Read ↗

TBX21 and HLX1 polymorphisms influence cytokine secretion at birth.Semantic proximity Read ↗

HLX1 gene variants influence the development of childhood asthma.Semantic proximity Read ↗

Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children.Semantic proximity Read ↗

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.Semantic proximity Read ↗

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.Semantic proximity Read ↗

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.Semantic proximity Read ↗

17q12-21 and asthma: interactions with early-life environmental exposures.Semantic proximity Read ↗

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.Semantic proximity Read ↗

A common exonic variant of interleukin21 confers susceptibility to atopic asthma.Semantic proximity Read ↗

A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.Semantic proximity Read ↗

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