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Article

TBX21 and HLX1 polymorphisms influence cytokine secretion at birth.

PloS one - 1 Jan 2012

Casaca Vera Isabel, Illi Sabina, Suttner Kathrin, Schleich Isolde, Ballenberger Nikolaus, Klucker Elizabeth, Turan Elif, von Mutius Erika, Kabesch Michael, Schaub Bianca

Abstract excerpt

BACKGROUND: TBX21 (T cell specific T-box transcription factor) and HLX1 (H.20-like homeobox 1) are crucial transcription factors of T(H)1-cells, inducing their differentiation and suppressing T(H)2 commitment, particularly important for early life immune development. This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated...

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Source

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Identifiers

PMID: 22303482
DOI: 10.1371/journal.pone.0031069
PMCID: PMC3268767

Genes

TBX21
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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