Article
T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children.
The Journal of allergy and clinical immunology - 1 Jan 2008
Munthe-Kaas Monica Cheng, Carlsen Kai Håkon, Håland Geir, Devulapalli Chandra Sekhar, Gervin Kristina, Egeland Thore, Carlsen Karin Lødrup, Undlien Dag
Abstract excerpt
BACKGROUND: T cell-specific T-box transcription factor (T-bet) is a member of the T-box family of transcription factors regulating lineage commitment of T(H) lymphocytes toward a predominant T(H)1 phenotype. Asthma and allergy are common complex diseases characterized by T(H)2-mediated inflammation. OBJECTIVE: We aimed to assess possible relationships between the T-bet gene (TBX21) and asthma and allergy in...
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