Article
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
Human genetics - 1 Jun 2005
Akahoshi Mitsuteru, Obara Kazuhiko, Hirota Tomomitsu, Matsuda Akira, Hasegawa Koichi, Takahashi Naomi, Shimizu Makiko, Nakashima Kazuko, Cheng Lei, Doi Satoru, Fujiwara Hiroshi, Miyatake Akihiko, Fujita Kimie, Higashi Noritaka, Taniguchi Masami, Enomoto Tadao, Mao Xiao-Quan, Nakashima Hitoshi, Adra Chaker N, Nakamura Yusuke, Tamari Mayumi, Shirakawa Taro
Abstract excerpt
Asthma is a phenotypically heterogeneous disorder with many etiologic factors and clinical characteristics. T-bet, a Th1-specific transcription factor of T-box family, has been found to control interferon-gamma (IFN-gamma) expression in T cells. Mice lacking the T-bet gene (tbx21) demonstrate multiple physiological and inflammatory features reminiscent of human asthma. In order to examine whether polymorphisms in...
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