Article
A common exonic variant of interleukin21 confers susceptibility to atopic asthma.
International archives of allergy and immunology - 1 Jan 2009
Chatterjee Rajshekhar, Batra Jyotsna, Ghosh Balaram
Abstract excerpt
BACKGROUND: Interleukin (IL)-21, an IL-2 family multifunctional cytokine, is produced by activated CD4+ T cells and is known to potentially affect growth, survival and function of numerous immune cells. As IL-21 regulates IgE production, a key mediator of various allergic disorders and asthma, it is a prime candidate gene for studying atopic asthma. METHODS: In atopic asthma, analyses of four single nucleotide...
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