Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children.

Journal of human genetics - 1 Aug 2014

Sharma Neeraj, Jaiswal Indu, Mandal Raju K, Phadke Shubha R, Awasthi Shally

Abstract excerpt

T-box transcription factor protein (TBX21) is encoded by the TBX21 gene in human. It is crucial for naive T lymphocyte development, interferon-γ production, airway hyperresponsiveness and regulation of corticosteroid response in asthmatics. Polymorphisms rs4794067 and rs16947078 of TBX21 were found to be associated with acetylsalicylic acid-induced and allergic asthma, respectively. We examined whether sequence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Asthma

Share to Genetic Association Studies

Share to Severity of Illness Index

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 25056814
DOI: 10.1038/jhg.2014.52

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children.PMID 25056814Read ↗

Association analysis of novel TBX21 variants with asthma phenotypes.Semantic proximity Read ↗

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.Semantic proximity Read ↗

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.Semantic proximity Read ↗

Genetic Variations on Chromosome 6p21 Are Associated with Asthma Risk and Disease Severity: A Case-Control Study from Pakistan.Semantic proximity Read ↗

T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children.Semantic proximity Read ↗

17q21 locus rs7216389 polymorphism and childhood asthma risk: a meta-analysis.Semantic proximity Read ↗

Association between 17q21 variants and asthma predisposition in Pashtun population from Pakistan.Semantic proximity Read ↗

Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population.Semantic proximity Read ↗

Asthma and atopy are associated with chromosome 17q21 markers in Chinese children.Semantic proximity Read ↗

Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study.Semantic proximity Read ↗

Association Between TGF-β1 Polymorphisms and Asthma Susceptibility Among the Chinese: A Meta-Analysis.Semantic proximity Read ↗

Two single nucleotide polymorphisms in TSLP gene are associated with asthma susceptibility in Chinese Han population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.