Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association analysis of novel TBX21 variants with asthma phenotypes.

Human mutation - 1 Sept 2003

Chung Hun Taek, Kim Lyoung Hyo, Park Byung Lae, Lee June Hyuk, Park Hae-Sim, Choi Byoung Whui, Hong Soo-Jong, Chae Soo Cheon, Kim Jeong Joong, Park Choon-Sik, Shin Hyoung Doo

Abstract excerpt

Human TBX21 expressed in T Cells (T-BOX21) is a Th1-specific T-box transcription factor that controls the expression of the hallmark Th1 cytokine, IFNG. As a potent candidate gene for asthma genetic study, we have sequenced the full gene of human TBX21, including the -1,500bp promoter region to identify its gene polymorphisms. Twenty-three single nucleotide polymorphisms (SNPs) were identified; one in promoter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Asthma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Gene Frequency

Share to Haplotypes

Share to Linkage Disequilibrium

Share to T-bet Transcription Factor

Share to T-Box Domain Proteins

Source

Identifiers

PMID: 12938094
DOI: 10.1002/humu.9169

Genes

TBX21
IFNG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association analysis of novel TBX21 variants with asthma phenotypes.PMID 12938094Read ↗

TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants.Semantic proximity Read ↗

Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.Semantic proximity Read ↗

Genetic variation of TBX21 gene increases risk of asthma and its severity in Indian children.Semantic proximity Read ↗

T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.Semantic proximity Read ↗

T cell-specific T-box transcription factor haplotype is associated with allergic asthma in children.Semantic proximity Read ↗

17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells.Semantic proximity Read ↗

The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.Semantic proximity Read ↗

Genetic variants on 17q21 are associated with asthma in a Han Chinese population.Semantic proximity Read ↗

A common exonic variant of interleukin21 confers susceptibility to atopic asthma.Semantic proximity Read ↗

A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.Semantic proximity Read ↗

TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids.Semantic proximity Read ↗

17q12-21 variants are associated with asthma and interact with active smoking in an adult population from the United Kingdom.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.