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Article

A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.

Scandinavian journal of immunology - 1 May 2011

Li J-R, Li J-G, Deng G-H, Zhao W-L, Dan Y-J, Wang Y-M, Chen S

Abstract excerpt

T-bet is a key regulator for the lineage commitment in CD4 T helper (Th) 1 cells by activating the hallmark production of interferon-γ, and its expression level is linked to autoimmune, infectious, and allergic diseases. A T to C base substitution has been identified at position -1993 in the TBX21 (encoding T-bet) promoter and has been associated with asthma and systemic lupus erythematosus. This study aimed to...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophoretic Mobility Shift Assay

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Source

Identifiers

PMID: 21272048
DOI: 10.1111/j.1365-3083.2011.02520.x

Genes

TBX21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression.PMID 21272048Read ↗

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The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.Semantic proximity Read ↗

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