Article
Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.
BMC developmental biology - 8 Apr 2009
Miclea Razvan L, Karperien Marcel, Bosch Cathy Aj, van der Horst Geertje, van der Valk Martin A, Kobayashi Tatsuya, Kronenberg Henry M, Rawadi Georges, Akçakaya Pinar, Löwik Clemens Wgm, Fodde Riccardo, Wit Jan Maarten, Robanus-Maandag Els C
Abstract excerpt
BACKGROUND: During skeletogenesis, protein levels of beta-catenin in the canonical Wnt signaling pathway determine lineage commitment of skeletal precursor cells to osteoblasts and chondrocytes. Adenomatous polyposis coli (Apc) is a key controller of beta-catenin turnover by down-regulating intracellular levels of beta-catenin. RESULTS: To investigate whether Apc is involved in lineage commitment of skeletal...
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