Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.

Developmental biology - 15 Jan 2003

Ishikawa Tomo-o, Tamai Yoshitaka, Li Qin, Oshima Masanobu, Taketo Makoto M

Abstract excerpt

Tumor suppressor Apc (adenomatous polyposis coli) is implicated in the Wnt signaling pathway that is involved in the early embryonic development and tumorigenesis in vertebrates. While the heterozygous null mutant mice develop intestinal polyps, the homozygous embryos die before gastrulation. To investigate the role of Apc in later embryonic development, we constructed a novel hypomorphic Apc allele whose...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Chimera
Share to Embryonic and Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrula

Share to Genes, APC

Share to Homozygote

Share to In Situ Hybridization

Share to Lac Operon

Source

Identifiers

PMID: 12645927
DOI: 10.1016/s0012-1606(02)00020-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo.PMID 12645927Read ↗

Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.Semantic proximity Read ↗

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.Semantic proximity Read ↗

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo.Semantic proximity Read ↗

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis.Semantic proximity Read ↗

APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development.Semantic proximity Read ↗

Testing hypotheses for the functions of APC family proteins using null and truncation alleles in Drosophila.Semantic proximity Read ↗

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.Semantic proximity Read ↗

Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.Semantic proximity Read ↗

Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival.Semantic proximity Read ↗

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.Semantic proximity Read ↗

The adenomatous polyposis coli tumor suppressor and Wnt signaling in the regulation of apoptosis.Semantic proximity Read ↗

Homozygosity for the Min allele of Apc results in disruption of mouse development prior to gastrulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.