Article
Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes.
Developmental cell - 1 May 2005
Hill Theo P, Später Daniela, Taketo Makoto M, Birchmeier Walter, Hartmann Christine
Abstract excerpt
Osteoblasts and chondrocytes are involved in building up the vertebrate skeleton and are thought to differentiate from a common mesenchymal precursor, the osteo-chondroprogenitor. Although numerous transcription factors involved in chondrocyte and osteoblast differentiation have been identified, little is known about the signals controlling lineage decisions of the two cell types. Here, we show by conditionally...
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