Article
Apoptosis in neural crest cells by functional loss of APC tumor suppressor gene.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Hasegawa Sumitaka, Sato Tomoyuki, Akazawa Hiroshi, Okada Hitoshi, Maeno Akiteru, Ito Masaki, Sugitani Yoshinobu, Shibata Hiroyuki, Miyazaki Ji Jun-ichi, Katsuki Motoya, Yamauchi Yasutaka, Yamamura Ki Ken-ichi, Katamine Shigeru, Noda Tetsuo
Abstract excerpt
Apc is a gene associated with familial adenomatous polyposis coli (FAP) and its inactivation is a critical step in colorectal tumor formation. The protein product, adenomatous polyposis coli (APC), acts to down-regulate intracellular levels of beta-catenin, a key signal transducer in the Wnt signaling. Conditional targeting of Apc in the neural crest of mice caused massive apoptosis of cephalic and cardiac neural...
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