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Article

Essential role of beta-catenin in postnatal bone acquisition.

The Journal of biological chemistry - 3 Jun 2005

Holmen Sheri L, Zylstra Cassandra R, Mukherjee Aditi, Sigler Robert E, Faugere Marie-Claude, Bouxsein Mary L, Deng Lianfu, Clemens Thomas L, Williams Bart O

Abstract excerpt

Mutations in the Wnt co-receptor LRP5 alter bone mass in humans, but the mechanisms responsible for Wnts actions in bone are unclear. To investigate the role of the classical Wnt signaling pathway in osteogenesis, we generated mice lacking the beta-catenin or adenomatous polyposis coli (Apc) genes in osteoblasts. Loss of beta-catenin produced severe osteopenia with striking increases in osteoclasts, whereas...

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Source

Identifiers

PMID: 15802266
DOI: 10.1074/jbc.M501900200

Genes

LRP5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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