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Article

The APC tumor suppressor is required for epithelial cell polarization and three-dimensional morphogenesis.

Biochimica et biophysica acta - 1 Mar 2015

Lesko Alyssa C, Goss Kathleen H, Yang Frank F, Schwertner Adam, Hulur Imge, Onel Kenan, Prosperi Jenifer R

Abstract excerpt

The Adenomatous Polyposis Coli (APC) tumor suppressor has been previously implicated in the control of apical-basal polarity; yet, the consequence of APC loss-of-function in epithelial polarization and morphogenesis has not been characterized. To test the hypothesis that APC is required for the establishment of normal epithelial polarity and morphogenesis programs, we generated APC-knockdown epithelial cell...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25578398
DOI: 10.1016/j.bbamcr.2014.12.036
PMCID: PMC4327896

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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