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Article

Dual positive and negative regulation of wingless signaling by adenomatous polyposis coli.

Science (New York, N.Y.) - 18 Jan 2008

Takacs Carter M, Baird Jason R, Hughes Edward G, Kent Sierra S, Benchabane Hassina, Paik Raehum, Ahmed Yashi

Abstract excerpt

The evolutionarily conserved Wnt/Wingless signal transduction pathway directs cell proliferation, cell fate, and cell death during development in metazoans and is inappropriately activated in several types of cancer. The majority of colorectal carcinomas contain truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor, a negative regulator of Wnt/Wingless signaling. Here, we demonstrate that...

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PMID: 18202290
DOI: 10.1126/science.1151232

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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