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Article

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

9 Jul 2009

Abstract excerpt

The role of Notch signaling in cartilage differentiation and maturation in vivo was examined. Conditional Notch pathway gain and loss of function was achieved using a Cre/loxP approach to manipulate Notch signaling in cartilage precursors and chondrocytes of the developing mouse embryo. Conditional overexpression of activated Notch intracellular domain (NICD) in the chondrocyte lineage results in skeletal...

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PMID: 19590010
DOI: 10.1073/pnas.0902306106

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