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Article

Developmental regulation of Wnt/beta-catenin signals is required for growth plate assembly, cartilage integrity, and endochondral ossification.

The Journal of biological chemistry - 13 May 2005

Tamamura Yoshihiro, Otani Tomohiro, Kanatani Naoko, Koyama Eiki, Kitagaki Jirota, Komori Toshihisa, Yamada Yoshihiko, Costantini Frank, Wakisaka Satoshi, Pacifici Maurizio, Iwamoto Masahiro, Enomoto-Iwamoto Motomi

Abstract excerpt

Studies have suggested that continuous Wnt/beta-catenin signaling in nascent cartilaginous skeletal elements blocks chondrocyte hypertrophy and endochondral ossification, whereas signaling starting at later stages stimulates hypertrophy and ossification, indicating that Wnt/beta-catenin roles are...

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Identifiers

PMID: 15760903
DOI: 10.1074/jbc.M414275200

Genes

ADAMTS5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15760903-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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