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Article

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

PLoS genetics - 15 Sept 2006

Kuraguchi Mari, Wang Xiu-Ping, Bronson Roderick T, Rothenberg Rebecca, Ohene-Baah Nana Yaw, Lund Jennifer J, Kucherlapati Melanie, Maas Richard L, Kucherlapati Raju

Abstract excerpt

The tumor suppressor gene Apc (adenomatous polyposis coli) is a member of the Wnt signaling pathway that is involved in development and tumorigenesis. Heterozygous knockout mice for Apc have a tumor predisposition phenotype and homozygosity leads to embryonic lethality. To understand the role of Apc in development we generated a floxed allele. These mice were mated with a strain carrying Cre recombinase under the...

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Source

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Identifiers

PMID: 17002498
DOI: 10.1371/journal.pgen.0020146
PMCID: PMC1564426

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.PMID 17002498Read ↗

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Targeted Disruption of Smad4 in Mouse Epidermis Results in Failure of Hair Follicle Cycling and Formation of Skin TumorsSemantic proximity Read ↗

Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors.Semantic proximity Read ↗

Loss of adenomatous polyposis coli gene function disrupts thymic development.Semantic proximity Read ↗

APC and its modifiers in colon cancer.Semantic proximity Read ↗

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Cystic Renal Neoplasia Following Conditional Inactivation of Apc in Mouse Renal Tubular EpitheliumSemantic proximity Read ↗

A common human skin tumour is caused by activating mutations in beta-catenin.Semantic proximity Read ↗

Exploiting APC Function as a Novel Cancer TherapySemantic proximity Read ↗

Complete deletion of Apc results in severe polyposis in mice.Semantic proximity Read ↗

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