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Article

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling.

Nature genetics - 1 Dec 2002

Kielman Menno F, Rindapää Maaret, Gaspar Claudia, van Poppel Nicole, Breukel Cor, van Leeuwen Sandra, Taketo Makoto Mark, Roberts Scott, Smits Ron, Fodde Riccardo

Abstract excerpt

The Wnt signal-transduction pathway induces the nuclear translocation of membrane-bound beta-catenin (Catnb) and has a key role in cell-fate determination. Tight somatic regulation of this signal is essential, as uncontrolled nuclear accumulation of beta-catenin can cause developmental defects an...

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Source

Identifiers

PMID: 12426568
DOI: 10.1038/ng1045

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12426568-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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